Serum concentration of high density lipoproteins (HDLs) in leishmaniotic dogs. (February 2015)

• Record Type: Journal Article
• Authors: Ibba, Fabrizio; Rossi, Gabriele; Meazzi, Sara; Giordano, Alessia; Paltrinieri, Saverio
• Is Part Of: Research in veterinary science. Volume 98(2015)
• Page Start: 89
• Page End: 91
• Publication Date: 2015-02
• Subjects: CL canine leishmaniasis -- Chol total cholesterol -- CKD chronic kidney disease -- CRP C-reactive protein -- HDL high density lipoprotein -- HDL-chol HDL-cholesterol (mg/ml) -- HDL% percentage of HDL-chol on total chol -- PON-1 paraoxonase-1; Clinical pathology -- Parasitology -- Companion animal medicine -- Canine leishmaniasis -- Inflammation; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Médecine vétérinaire -- Recherche -- Périodiques; Diergeneeskunde; 636.089
• DOI: 10.1016/j.rvsc.2014.11.011
• Languages: English
• ISSNs: 0034-5288

Abstract

Highlights: Serum levels of high density lipoproteins (HDLs) are influenced by oxidative stress. Oxidative stress associated with inflammation is present in leishmaniotic dogs. HDLs and the antioxidant enzyme PON-1 were measured in leishmaniotic dogs. HDLs and PON-1 were low in leishmaniotic dogs likely due to oxidative stress. HDLs increase after treatment and may be used to monitor the response to treatments. Abstract: In order to assess whether the concentration of high density lipoproteins (HDLs) changes in leishmaniotic dogs before and after treatment, HDL cholesterol (HDL-Chol and HDL%), C reactive protein (CRP) and activity of the antioxidant enzyme paraoxonase (PON-1) were measured in sera from 10 controls and 10 leishmaniotic dogs. Seven of these latter were sampled also 3, 7, 14, 21 and 28 days after treatment with antimonials and allopurinol. HDL-chol, and PON-1 were low in leishmaniotic dogs at admission and increased after treatment. HDL-chol and HDL% correlated positively with PON-1 and negatively with CRP suggesting that HDLs decrease through an oxidative mechanism. Therefore, HDLs may be used to monitor the magnitude of oxidation associated with inflammation in leishmaniotic dogs.