ACTH-Independent Cushing's Syndrome Associated with Left Adrenocortical Oncocytoma of Uncertain Malignant Potential. (27th September 2020)

• Record Type: Journal Article
• Authors: Sica, Giuseppe S.; Siragusa, Leandro; Sensi, Bruno; Bellato, Vittoria; Floris, Pierangela; Rovella, Valentina; Mauriello, Alessandro; Di Prete, Monia; Telesca, Rossana; Ciavoni, Valerio; Cardillo, Carmine; Di Daniele, Nicola; Tesauro, Manfredi
• Other Names: Isozaki Osamu Academic Editor.
• Is Part Of: Case reports in endocrinology. Volume 2020(2020)
• Publication Date: 2020-09-27
• Subjects: Endocrinology -- Periodicals; Endocrinology -- Case studies -- Periodicals; Endocrine glands -- Diseases -- Periodicals; Endocrinology; Endocrine System Diseases; Endocrine glands -- Diseases; Endocrinology; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.4
• DOI: 10.1155/2020/8816527
• Languages: English
• ISSNs: 2090-6501

Abstract

Abstract : Adrenocortical oncocytomas are rare and mostly nonfunctioning neoplasms. We report the case of a 27-year-old woman diagnosed with an ACTH-independent Cushing's syndrome due to left adrenal oncocytoma. She underwent laparoscopic adrenalectomy. Histopathological examination revealed an oncocytoma of uncertain malignant potential with a low Ki-67 proliferation index, inhibin A positivity, and chromogranin A negativity. Electron micrographs confirmed adrenal oncocytoma cells, characterized by the presence of a large amount of mitochondria. The postoperative course was uneventful, and the patient experienced a progressive regression of Cushing-related symptoms. Periodical follow-ups with MRI and cortisol dosage are required due to the neoplasm's uncertain malignant potential. Considerations on the diagnosis, pathology findings, clinical remarks, and interventions are made.