Differential influences of the BPA, BPS and BPF on in vitro IL-17 secretion by mouse and human T cells. (December 2020)

• Record Type: Journal Article
• Authors: Malaisé, Yann; Le Mentec, Hélène; Sparfel, Lydie; Guzylack-Piriou, Laurence
• Is Part Of: Toxicology in vitro. Volume 69(2020)
• Publication Date: 2020-12
• Subjects: Bisphenols -- Mice -- Human -- IL-17 secretion -- Th17 differentiation -- In vitro; Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2020.104993
• Languages: English
• ISSNs: 0887-2333

Abstract

Abstract: The endocrine disruptor and food contaminant bisphenol A (BPA) is frequently present in consumer plastics and can produce several adverse health effects participating in the development of inflammatory and autoimmune diseases. Regulatory restrictions have been established to prevent risks for human health, leading to the substitution of BPA by structural analogues, such as bisphenol S (BPS) and F (BPF). In this study, we aimed at comparing the in vitro impact of these bisphenols from 0.05 to 50, 000 nM on Th17 differentiation, frequency and function in mouse systemic and intestinal immune T cells and in human blood T cells. This study reports the ability of these bisphenols, at low and environmentally relevant concentration, i.e, 0.05 nM, to increase significantly IL-17 production in mouse T cells but not in human T lymphocytes. The use of an aryl hydrocarbon receptor (AhR) specific inhibitor demonstrated its involvement in this bisphenol-induced IL-17 production. We also observed an increased IL-17 secretion by BPS and BPF, and not by BPA, in mouse naive T cells undergoing in vitro Th17 differentiation. In total, this study emphasizes the link between bisphenol exposures and the susceptibility to develop immune diseases, questioning thus the rational of their use to replace BPA. Highlights: In vitro exposure to bisphenols A, S, F differentially alter IL-17 secretion by mouse T cells. Such effect occurs at low and environmentally relevant concentrations. Such effect is partly mediated by aryl hydrocarbon receptor activation. Effects of bisphenols A, S, F on IL-17 secretion are different in human and mouse T cells.