Cerebellar volume loss in radiologically isolated syndrome. (January 2021)

• Record Type: Journal Article
• Authors: George, Ilena C; El Mendili, Mohamed Mounir; Inglese, Matilde; Azevedo, Christina J; Kantarci, Orhun; Lebrun, Christine; Siva, Aksel; Okuda, Darin T; Pelletier, Daniel
• Is Part Of: Multiple sclerosis. Volume 27:Number 1(2021)
• Page Start: 130
• Page End: 133
• Publication Date: 2021-01
• Subjects: Radiologically isolated syndrome -- multiple sclerosis -- cerebellum -- brainstem -- cerebellar atrophy -- white matter lesions; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458519887346
• Languages: English
• ISSNs: 1352-4585

Abstract

Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC ( p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.