Delayed Healing of Tooth Extraction Sockets with Ramucirumab Use. (1st October 2020)

• Record Type: Journal Article
• Authors: Iijima, Yosuke; Yamada, Miki; Hino, Shunsuke; Sano, Motohiko; Kaneko, Takahiro; Horie, Norio
• Other Names: Macan Darko Academic Editor.
• Is Part Of: Case reports in dentistry. Volume 2020(2020)
• Publication Date: 2020-10-01
• Subjects: Dentistry -- Case studies -- Periodicals; Oral medicine -- Case studies -- Periodicals; Oral Medicine; Dentistry; Dentistry; Oral medicine; Electronic journals; Periodical; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 617.6
• DOI: 10.1155/2020/8881749
• Languages: English
• ISSNs: 2090-6447

Abstract

Abstract : Objective . An angiogenesis inhibitor can cause medication-related osteonecrosis of the jaw (MRONJ). To our knowledge, there has been no report that an angiogenesis inhibitor causes delayed healing of tooth extraction socket. Here, we describe a case of delayed healing of tooth extraction sockets associated with an angiogenesis inhibitor, ramucirumab, which showed characteristics similar to MRONJ. Materials and Methods . A 76-year-old male patient, who was diagnosed with gastric cancer with liver metastasis, received tooth extraction twice during continuous chemotherapy comprising paclitaxel and ramucirumab. Results . The first extraction was performed 30 days after ramucirumab discontinuation without complication. The second extraction was conducted without ramucirumab discontinuation. Although tooth socket healing was finally achieved, it took about 150 days. Discussion . This case was considered to be delayed healing of dry sockets rather than MRONJ due to ramucirumab. Dentists and oral surgeons need to be aware that angiogenesis inhibitors can cause not only MRONJ but also dry sockets after tooth extraction.