Synthesis and Antimicrobial Resistant Modulatory Activity of 2, 4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens. (7th October 2020)

• Record Type: Journal Article
• Authors: Ade, Alberta; Amengor, Cedric D. K.; Brobbey, Abena; Ayensu, Isaac; Harley, Benjamin K.; Boakye, Yaw Duah
• Other Names: Mancini Pedro M. Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2020(2020)
• Publication Date: 2020-10-07
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2020/2720697
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : A library of six novel phenylhydrazones were synthesized and evaluated for their in vitro antimicrobial and resistance modulating activity against a panel of Gram-positive, Gram-negative, and fungal species. The compounds were produced in good yields of 60–92% w/w and characterized using melting point, UV-visible spectroscopy, infrared, and nuclear magnetic resonance ( 1 H, 13 C, and DEPT-Q) techniques. Mass spectroscopy was used to confirm the identity of one of the most active compounds, 5 [SA5]. The phenylhydrazones showed activity against all the six selected microorganisms with minimum inhibitory concentration (MIC) values of the most active compounds, 1 [BP1] and 5 [SA5], at 138 µ M ( Klebsiella pneumoniae ) and 165 µ M ( Streptococcus pneumoniae ), respectively. Compound 1 [BP1] further demonstrated a high resistance modulatory activity at 1.078 µ M against Streptococcus pneumoniae and Klebsiella pneumoniae.