Mortality of Alzheimer's Disease Patients: A 10-Year Follow-up Pilot Study in Shanghai. (March 2020)

• Record Type: Journal Article
• Authors: Zhang, Yue-Qi; Wang, Chun-Fang; Xu, Gang; Zhao, Qian-Hua; Xie, Xin-Yi; Cui, Hai-Lun; Wang, Ying; Ren, Ru-Jing; Guo, Qi-Hao; Wang, Gang
• Is Part Of: Canadian journal of neurological sciences. Volume 47:Number 2(2020)
• Page Start: 226
• Page End: 230
• Publication Date: 2020-03
• Subjects: Alzheimer's disease, -- Mortality, -- Standardized mortality ratio, -- Diabetes mellitus; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Electronic journals; 616.8
• DOI: 10.1017/cjn.2019.333
• Languages: English
• ISSNs: 0317-1671

Abstract

ABSTRACT: Background: Identifying risk factors and mortality of individuals with Alzheimer's disease (AD) could have important implications for the clinical management of AD. Objective: This pilot study aimed to examine the overall mortality of AD patients over a 10-year surveillance period in Shanghai, China. This study is an extension of our previous investigation on mortality of neurodegenerative diseases. Methods: One hundred and thirty-two AD patients recruited from the memory clinics of two hospitals in Shanghai in 2007 were followed up until December 31, 2017 or death, representing a follow-up period of up to 10 years. Overall standardized mortality ratios (SMRs) were calculated, and predictors for survival at recruitment were estimated. Results: Sixty-seven patients had died by December 31, 2017, and the SMR at 10 years of follow-up was 1.225 (95% confidence interval 0.944–1.563). Employing Cox's proportional hazard modeling, lower Mini-Mental State Examination score, and comorbid diabetes predicted poor survival in this cohort. Conclusion: This pilot study suggests a similar survival trend of patients with AD compared to the general population in Shanghai urban region. Poor cognitive status and comorbid diabetes had a negative impact on the survival of AD patients.