The impact of comorbid depression–diabetes on proteomic outcomes among community-dwelling Mexican Americans with mild cognitive impairment. (January 2020)

• Record Type: Journal Article
• Authors: Johnson, Leigh Ann; Zhang, Fan; Large, Stephanie; Hall, James; O'Bryant, Sidney E.
• Is Part Of: International psychogeriatrics. Volume 32:Number 1(2020)
• Page Start: 17
• Page End: 23
• Publication Date: 2020-01
• Subjects: Mexican Americans, -- diabetes mellitus, -- depression, -- proteomics; Geriatric psychiatry -- Periodicals; 618.9768905
• DOI: 10.1017/S1041610219001625
• Languages: English
• ISSNs: 1041-6102

Abstract

ABSTRACT: Background: Mexican Americans suffer from a disproportionate burden of modifiable risk factors, which may contribute to the health disparities in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Objective: The purpose of this study was to elucidate the impact of comorbid depression and diabetes on proteomic outcomes among community-dwelling Mexican American adults and elders. Methods: Data from participants enrolled in the Health and Aging Brain among Latino Elders study was utilized. Participants were 50 or older and identified as Mexican American ( N = 514). Cognition was assessed via neuropsychological test battery and diagnoses of MCI and AD adjudicated by consensus review. The sample was stratified into four groups: Depression only, Neither depression nor diabetes, Diabetes only, and Comorbid depression and diabetes. Proteomic profiles were created via support vector machine analyses. Results: In Mexican Americans, the proteomic profile of MCI may change based upon the presence of diabetes. The profile has a strong inflammatory component and diabetes increases metabolic markers in the profile. Conclusion: Medical comorbidities may impact the proteomics of MCI and AD, which lend support for a precision medicine approach to treating this disease.