Age at Onset of LRRK2 p.Gly2019Ser Is Related to Environmental and Lifestyle Factors. Issue 10 (2nd September 2020)

• Record Type: Journal Article
• Authors: Lüth, Theresa; König, Inke R.; Grünewald, Anne; Kasten, Meike; Klein, Christine; Hentati, Faycel; Farrer, Matthew; Trinh, Joanne
• Is Part Of: Movement disorders. Volume 35:Issue 10(2020)
• Page Start: 1854
• Page End: 1858
• Publication Date: 2020-09-02
• Subjects: LRRK2 -- environment -- age at onset -- smoking -- black tea -- modifiers -- penetrance; Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.28238
• Languages: English
• ISSNs: 0885-3185

Abstract

ABSTRACT: Objectives: The effect of environmental and lifestyle factors on patients with LRRK2 (leucine‐rich repeat kinase 2) p.Gly2019Ser (LRRK2 + /PD + ) compared to idiopathic PD (iPD) has yet to be thoroughly investigated. Methods: In a homogeneous Tunisian Arab Berber population, we recruited 200 idiopathic PD and 199 LRRK2 p.Gly2019Ser mutation carriers, of whom 142 had PD (LRRK2 + /PD + ) and 57 were unaffected (LRRK2 + /PD − ). Case report form (CRF) questionnaires (motor and non‐motor symptoms) including the Geoparkinson Questionnaire were used to assess environmental and lifestyle factors. Results: In LRRK2 + /PD +, tobacco use was significantly associated with a later median age at onset (AAO). The median AAO was 60 years (interquartile range = 52–67.25) for tobacco users, compared to 52 years (interquartile range = 45.25–61) for non‐users ( P = 0.0042 at adjusted α = 0.025). Additionally, we observed an independent but additive effect of black tea consumption and tobacco use. Conclusions: Our data suggest that tobacco and black tea have a protective effect on age at onset in LRRK2 + /PD + . © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.