Gating and regulation of the calcium release‐activated calcium channel: Recent progress from experiments and molecular modeling. Issue 10 (10th September 2020)

• Record Type: Journal Article
• Authors: Huo, Jun; Dong, Hao
• Is Part Of: Biopolymers. Volume 111:Issue 10(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-09-10
• Subjects: 2‐APB -- CRAC channel -- gating mechanism -- molecular modeling -- mutation; Biopolymers -- Periodicals; Peptides -- Periodicals; Spectrum analysis -- Periodicals; 572.33
• DOI: 10.1002/bip.23392
• Languages: English
• ISSNs: 0006-3525

Abstract

Abstract: Calcium release‐activated calcium (CRAC) channels are highly calcium ion (Ca 2+ )‐selective channels in the plasma membrane. The transient drop of endoplasmic reticulum Ca 2+ level activates its calcium sensor stromal interaction molecule (STIM) and then triggers the gating of the CRAC channel pore unit Orai. This process involves a variety of activities of the immune system. Therefore, understanding how the activation and regulation of the CRAC channel can be accomplished is essential. Here we briefly summarize the recent progress on Orai gating and its regulation by 2‐aminoethoxydiphenylborate (2‐APB) obtained from structural biology studies, biochemical and electrophysiological measurements, as well as molecular modeling. Indeed, integration between experiments and computations has further deepened our understanding of the channel gating and regulation. Abstract :