Ethnicity-Stratified Analysis of the Association between TNF-α Genetic Polymorphisms and Acute Kidney Injury: A Systematic Review and Meta-Analysis. (5th October 2020) - Chen, Guanzhong
Abstract : Background . Several studies have reported conflicting findings regarding the association between tumor necrosis factor-alpha (TNF- α ) genetic polymorphisms and acute kidney injury (AKI). Therefore, we performed this meta-analysis to further investigate whether TNF- α variants are related to AKI susceptibility. Methods . A comprehensive search of observational studies on the association of TNF- α polymorphism with AKI susceptibility was conducted in the PubMed, Cochrane, and Embase databases through February 10, 2020. Pooled odds ratios (ORs) and 95% corresponding confidence intervals (95% CIs) were analyzed to evaluate the strength of the relationship. Results . A total of 8 studies involving 6694 patients (2559 cases and 4135 controls) were included. Pooled analysis showed a trend of increased risk between the TNF- α rs1800629 variant and AKI (A vs. G: OR 95 % CI = 1.33 0.98 ‐ 1.81 ) among the overall population. Ethnicity-stratified analysis indicated that the TNF- α rs1800629 variant was a risk factor for Asians (OR 95 % CI = 1.93 1.59 ‐ 2.35 ) while it is not for Caucasians (OR 95 % CI = 1.04 0.91 ‐ 1.20 ). Additionally, we also found that TNF- α rs1799964 polymorphism was observed to have a significant relationship with AKI risk in Asian patients (C vs. T, OR 95 % CI = 1.26 1.11 ‐ 1.43 ). Conclusions . The TNF rs1800629 polymorphism exhibited a trend toward AKI susceptibility with ethnic differences. The relationship was found to be significant among the Asian population, but not among those of Caucasian origin. Additionally, the TNF- α rs1799964 polymorphism was also related to a significantly increased risk of AKI in Asians.