Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature. (August 2020)

• Record Type: Journal Article
• Authors: Lemieux, Alexandre; Ran Cai, Zhuo; Belisle, Annie; Chartier, Suzanne; Bolduc, Chantal
• Is Part Of: SAGE open medical case reports. Volume 8(2020)
• Publication Date: 2020-08
• Subjects: Pyoderma gangrenosum -- levamisole -- cocaine; Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1177/2050313X20935736
• Languages: English
• ISSNs: 2050-313X

Abstract

Pyoderma gangrenosum is often associated with a systemic disease. Cocaine-induced pyoderma gangrenosum, most probably caused by levamisole, has been described recently and typically presents as multiple, large cribriform ulcers. Peri-nuclear antineutrophil cytoplasmic antibody is the most common serological finding. A strong counseling for cocaine cessation, combined with wound care and immunosuppressive therapy, is the mainstay of treatment. We present two cases of cocaine-induced pyoderma gangrenosum and correlate their findings with the typical clinical, histological and serological presentation.