Sustained drug retention after paclitaxel-coated balloon angioplasty for superficial femoral artery disease: Follow-up intravascular imaging. (February 2020)

• Record Type: Journal Article
• Authors: Kobayashi, Norihiro; Hirano, Keisuke; Yamawaki, Masahiro; Araki, Motoharu; Sakai, Tsuyoshi; Sakamoto, Yasunari; Mori, Shinsuke; Tsutsumi, Masakazu; Nauchi, Masahiro; Sahara, Naohiko; Honda, Yohsuke; Makino, Kenji; Shirai, Shigemitsu; Mizusawa, Masafumi; Sugizaki, Yuta; Nakano, Takahide; Fukagawa, Tomoya; Kishida, Toshihiko; Kozai, Yuki; Setonaga, Yusuke; Goda, Shutaro; Ito, Yoshiaki
• Is Part Of: SAGE open medical case reports. Volume 8(2020)
• Publication Date: 2020-02
• Subjects: Paclitaxel-coated balloon -- superficial femoral artery disease -- optical frequency domain imaging -- optical coherence tomography; Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1177/2050313X20907825
• Languages: English
• ISSNs: 2050-313X

Abstract

A 63 year-old woman with claudication underwent endovascular therapy for diffuse stenosis of the right superficial femoral artery in our hospital. We performed paclitaxel-coated balloon angioplasty using the IN.PACT™ Admiral™ and achieved acceptable results. After 42 days, we performed follow-up optical frequency domain imaging for the right superficial femoral artery lesion treated with paclitaxel-coated balloon and observed several high-intensity regions with attenuation on the lumen surface. Sustained drug availability is a notable characteristic of paclitaxel-coated balloon. To the best of our knowledge, this is the first report on the visualization of sustained drug retention on the lumen surface using follow-up optical frequency domain imaging after paclitaxel-coated balloon angioplasty in a human patient with superficial femoral artery disease.