The genetic polymorphisms of angiotensin converting enzyme insertion/deletion and glioma susceptibility: A meta-analysis. (October 2020)

• Record Type: Journal Article
• Authors: Sun, Meili; Fang, Yuying; Ma, Shuzhen; Gao, Ximei; Sun, Yuping
• Is Part Of: Journal of the renin-angiotensin-aldosterone system. Volume 21:Number 4(2020)
• Publication Date: 2020-10
• Subjects: Angiotensin converting enzyme -- gene -- polymorphism -- glioma -- meta-analysis; Renin-angiotensin system -- Periodicals; 616.132
• DOI: 10.1177/1470320320963939
• Languages: English
• ISSNs: 1470-3203

Abstract

Objective: The previous studies on angiotensin converting enzyme (ACE) insertion/deletion (I/D) genetic polymorphism and glioma risk were inconsistent. Therefore, we performed a meta-analysis to assess the association between ACE I/D polymorphisms and glioma risk. Methods and Results: In total, four populations (1110 cases and 1335 controls) on ACE I/D polymorphism were included. Overall, the meta-analysis demonstrated no significant association between ACE I/D polymorphism and glioma risk. In addition, the analysis of the association of ACE I/D polymorphism and clinical grade also showed no significant association. Conclusion: Our meta-analysis didn't find a significant association between ACE I/D polymorphism glioma risk. However, further studies with larger sample size and more ethnic groups are required to confirm the results.