Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity. (13th July 2020)

• Record Type: Journal Article
• Authors: Carmona‐Maurici, Júlia; Amigó, Núria; Cuello, Elena; Bermúdez, Marcelino; Baena‐Fustegueras, Juan Antonio; Peinado‐Onsurbe, Julia; Pardina, Eva
• Is Part Of: European journal of clinical investigation. Volume 50:Number 11(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-13
• Subjects: 1H‐NMR -- atherosclerosis -- bariatric surgery -- glycoproteins -- morbid obesity -- oxidative stress; Pathology -- Periodicals; Medical research -- Periodicals; 616.075
• DOI: 10.1111/eci.13320
• Languages: English
• ISSNs: 0014-2972

Abstract

Abstract: Background: There is growing evidence that oxidative stress (OS) is a critical factor linking obesity with its associated comorbidities, such as cardiovascular diseases. Aim: To evaluate the degree of OS in people with morbid obesity and its relationship with glycoproteins, determined using 1H‐NMR spectroscopy, before and after bariatric surgery (BS). Methods: In this observational cohort study, plasma from 24 patients with BMI ≥ 40 kg/m 2 (age: 21‐65 years) was used to measure metabolites implicated in OS. We measured glycoprotein (GlycA, GlycB and GlycF) areas and shape factors (H/W = height/width). Results: One year after BS, oxidized low‐density lipoprotein had decreased by 49% ( P < .0001), malondialdehyde by 32% ( P = .0019) and lipoprotein (a) by 21% ( P = .0039). The antioxidant enzymes paraoxonase‐1 and catalase increased after BS (43%, P < .0001 and 54%, P = .0002, respectively). Superoxide dismutase‐2 had fallen 1 year after BS (32%, P = .0052). After BS, both the glycoprotein areas and shape factors decreased by 20%‐26%. These glycoproteins were significantly correlated with OS parameters. The plasma atherogenic index was 63% higher in obese individuals than 1 year after BS and correlated positively with glycoproteins. Conclusion: For the first time, we here demonstrate the relationship between OS parameters and glycoproteins in people with morbid obesity. So glycoproteins could therefore be a good indicator, together with the oxidative state to assess patient prognosis after BS.