Efficacy of Ethyl Acetate Fraction of Cordyceps militaris for Cancer-Related Fatigue in Blood Biochemical and 1H-Nuclear Magnetic Resonance Metabolomic Analyses. (June 2020)

• Record Type: Journal Article
• Authors: Oh, Junsang; Choi, Eunhyun; Kim, Jayoung; Kim, Heesu; Lee, Sangheun; Sung, Gi-Ho
• Is Part Of: Integrative cancer therapies. Volume 19(2020)
• Publication Date: 2020-06
• Subjects: cancer-related fatigue -- hepatocellular carcinoma -- Cordyceps militaris -- ethyl acetate fraction -- xenograft mouse model -- 1H-NMR metabolic profiling; Cancer -- Alternative treatment -- Periodicals; 616.99406
• DOI: 10.1177/1534735420932635
• Languages: English
• ISSNs: 1534-7354

Abstract

This study investigated the adjuvant effects for anticancer and antifatigue of the combination of Cordyceps militaris extract with sorafenib. The 5 extracts of C militaris were obtained through hexane, chloroform, ethyl acetate, butanol, and water and were evaluated for anticancer growth activity. Among these extracts, ethyl acetate extract of C militaris showed the best tumor growth inhibitory activity and the adjuvant effects in combination with sorafenib. As a result of biochemical analysis with serum, the combination of ethyl acetate extract of C militaris with sorafenib showed the adjuvant effects both improving hepatic function and relieving cancer-related fatigue. In addition, 1 H-nuclear magnetic resonance–based metabolic profiling in liver tissues showed that the change of metabolism by ethyl acetate extract of C militaris with sorafenib was related with serum fatigue biomarkers. Therefore, the combination strategy such as ethyl acetate extraction of C militaris with sorafenib constitutes a promising therapeutic strategy in hepatocellular carcinoma, via the inhibition of cancer growth, the enhancement of liver function, as well as the alleviation of cancer-related fatigue.