Designing Biodegradable Shape Memory Polymers for Tissue Repair. (16th July 2020)

• Record Type: Journal Article
• Authors: Ramaraju, Harsha; Akman, Ryan E.; Safranski, David L.; Hollister, Scott J.
• Is Part Of: Advanced functional materials. Volume 30:Number 44(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-16
• Subjects: biodegradation -- minimally invasive surgery -- regenerative medicine -- translational therapies; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202002014
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Shape memory materials, specifically nickel–titanium alloys, are used in a number of minimally invasive clinical procedures demonstrating significant improvements in clinical outcomes and standard of care compared to open procedures. However, concerns regarding erosion events, device failure, and consequent morbidities are driving interest in tissue engineering approaches which support or stimulate the patient's own tissue regenerative processes to repair and regenerate tissues. Growing interest in addressing these challenges using minimally invasive procedures is driving the rapid advancement of a new class of materials; biodegradable shape memory polymers (SMPs). These biodegradable SMPs are designed for compaction and delivery through keyhole incisions, expansion when they reach the target tissue, maintenance of mechanical continuity with surrounding tissues upon implantation, attachment of regenerative cells driving tissue growth and infiltration, and degradation into nontoxic byproducts. Polyesters are predominantly used in the design of these SMPs to impart biodegradability through hydrolysis. Use of homopolymers, copolymers, terpolymers, block‐copolymers, and interpenetrating networks has given rise to a range of SMPs spanning applications from endovascular to bone defect repair. Translating these materials to the clinic and applying these materials toward patient specific design can advance the current standard of care across various clinical disciplines. Abstract : Biodegradable shape memory polymers (SMPs) are designed for compaction and delivery through keyhole incisions, expansion upon reaching the target tissue, mechanical continuity with surrounding tissues, regeneration mediated by host and transplant cell populations, and degradation into nontoxic byproducts over an intended timeframe. SMP design strategies addressing a range of applications from endovascular to bone defect repair are herein reviewed.