"Do Not Ignore Musculoskeletal Pain"—Initial Presentation of a Rare Malignant Disease: Case Report and Literature Review. (July 2020)

• Record Type: Journal Article
• Authors: Patel, Ishan; Akoluk, Arda; Upadhyaya, Vandan; Makadia, Shraddhadevi; Douedi, Steven; Farooq, Taliya; Flynn, Daniel; Levitt, Michael; Hossain, Mohammad A.
• Is Part Of: Journal of investigative medicine high impact case reports. Volume 8(2020)
• Publication Date: 2020-07
• Subjects: gray zone lymphoma -- Hodgkin lymphoma -- EPOCH-R; Internal medicine -- Periodicals; Medical care -- Periodicals; 616.005
• DOI: 10.1177/2324709620941316
• Languages: English
• ISSNs: 2324-7096

Abstract

Gray zone lymphoma, also known as B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma, is a rare malignancy with overlapping features of both diffuse large B-cell lymphoma and classical Hodgkin lymphoma. Most commonly mediastinal involvement is seen. Extranodal involvement is rare. In this case report, we present the case of a 59-year-old male who presented with stress-related left shoulder pain, ultimately diagnosed with gray zone lymphoma. The patient was treated with etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin-rituximab (EPOCH-R) regimen followed by consolidation radiotherapy resulting in complete response. We are highlighting this case as rare and atypical presentation of a rare disease.