Spinal‐Cord Injury Treatment: Effective Modulation of CNS Inhibitory Microenvironment using Bioinspired Hybrid‐Nanoscaffold‐Based Therapeutic Interventions (Adv. Mater. 43/2020). Issue 43 (26th October 2020)

• Record Type: Journal Article
• Authors: Yang, Letao; Conley, Brian M.; Cerqueira, Susana R.; Pongkulapa, Thanapat; Wang, Shenqiang; Lee, Jae K.; Lee, Ki‐Bum
• Is Part Of: Advanced materials. Volume 32:Issue 43(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-26
• Subjects: biomaterials -- inorganic–organic hybrid nanomaterials -- nanoscaffolds -- neural tissue engineering -- spinal cord injury; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202070325
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Current treatment of central nervous system (CNS) injuries has been hampered by the neuroinhibitory microenvironment. In article number 2002578, Jae K. Lee, Ki‐Bum Lee, and co‐workers develop a method to effectively treat CNS injuries by delivering anti‐inflammatory drugs in vivo and providing a permissive neural matrix using biodegradable nanoscaffolds. Implantation of drug‐loaded nanoscaffolds to spinal‐cord injury sites reduces macrophage infiltration, suppresses fibrotic scarring, and thereby promotes functional recovery.