Increased association of coronary artery calcification in apparently healthy Korean adults with hypertriglyceridemic waist phenotype: The Kangbuk Samsung Health Study. (1st September 2015)

• Record Type: Journal Article
• Authors: Moon, Byung Sub; Park, Hye-Jeong; Lee, Min-Kyung; Jeon, Won Seon; Park, Se Eun; Park, Cheol-Young; Lee, Won-Yong; Oh, Ki-Won; Park, Sung-Woo; Rhee, Eun-Jung
• Is Part Of: International journal of cardiology. Volume 194(2015)
• Page Start: 78
• Page End: 82
• Publication Date: 2015-09-01
• Subjects: HTGW Hypertriglyceridemic waist -- CAC Coronary artery calcification -- CACS Coronary artery calcium score -- WC Waist circumference -- TG Triglyceride -- NWNT Normal waist circumference, normal triglyceride -- EWNT Enlarged waist circumference, normal triglyceride -- NWHT Normal waist circumference, high triglyceride -- EWHT Enlarged waist circumference, high triglyceride -- MetS Metabolic syndrome -- CVD Cardiovascular disease; Hypertriglyceridemia -- Abdominal obesity -- Coronary artery calcification; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2015.05.104
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Hypertriglyceridemic waist phenotype is a simple screening parameter to identify people at increased risk for cardiovascular disease. We evaluated whether hypertriglyceridemic waist (HTGW) phenotype increases the risk for coronary artery calcification (CAC) in apparently healthy Korean adults. Methods: A total of 32, 186 participants (mean age 41.3, 80.2% men) in a health screening program, in whom the coronary artery calcium score (CACS) was measured, were analyzed. Subjects were divided into four groups: 1) normal waist circumference (WC)–normal triglyceride (TG) (NWNT), 2) normal WC–high TG (NWHT), 3) enlarged WC–normal TG (EWNT), and 4) enlarged WC–high TG (EWHT). Enlarged WC was defined as WC ≥ 90 cm for men and ≥ 85 cm for women; high serum TG was defined as TG ≥ 150 mg/dL. The presence of CAC was defined by CACS > 0, and CACS was analyzed in a logarithmized form of CACS plus 1 {ln(CACS + 1)}. Results: A total of 14.9% of the participants had CAC. The EWHT group showed the highest mean value for ln(CACS + 1) among the four groups. The EWHT group showed the highest odds ratio for CAC, with NWHT group the second, and with EWNT group the third compared with the NWNT group after adjusting for confounding variables (1.579, 1.302, and 1.266 vs. NWNT). Conclusions: The EWHT group showed the highest association for CAC, suggesting this HTGW phenotype as a useful marker for the detection of subjects with high cardiometabolic risk in healthy Korean adults. Highlights: Hypertriglyceridemic waist (HTGW) phenotype is a simple screening method to predict cardiometabolic risk. The enlarged waist-hypertriglyceridemic (EWHT) group showed the highest risk for coronary artery calcification (CAC). NWHT and EWNT groups showed higher odds ratio for CAC compared with the NWNT group.