Synthesis and Anticancer Activity of N-(di/trimethoxyaryl)-5-arylisoxazole-3-carboxamide. (19th October 2020)

• Record Type: Journal Article
• Authors: Saeedi, Mina; Hashemi, Mehdi; Mahdavi, Mohammad; Rafinejad, Ali; Najafi, Zahra; Mirfazli, Seyedeh Sara; Mohammadian, Razieh; Karimpour-Razkenari, Elahe; Kabudanian Ardestani, Sussan; Safavi, Maliheh; Akbarzadeh, Tahmineh
• Is Part Of: Polycyclic aromatic compounds. Volume 40:Number 5(2020)
• Page Start: 1568
• Page End: 1580
• Publication Date: 2020-10-19
• Subjects: Anticancer -- apoptosis assay -- arylisoxazole -- carboxamide -- isoxazole -- synthesis; Polycyclic aromatic compounds -- Periodicals; 547
• DOI: 10.1080/10406638.2018.1564677
• Languages: English
• ISSNs: 1040-6638

Abstract

Abstract: In this study, a new series of N -(di or trimethoxyaryl)-5-arylisoxazole-3-carboxamide derivatives were synthesized and evaluated against human breast cancer cell lines including MCF-7, MDA-MB-231, and T-47D. Among the synthesized compounds, 5-( m -tolyl)- N -(3, 4, 5-trimethoxyphenyl)isoxazole-3-carboxamide (8f ) showed significant cytotoxicity against all three cell lines comparing with etoposide as the reference drug. Also, Annexin V-FITC/propidium iodide and acridine orange/ethidium bromide staining assay were performed to validate apoptotic activity of compound 8f . The results confirmed induction of apoptosis at early stage.