Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical Resection for Laryngeal Squamous Cell Carcinoma. (8th December 2020)

• Record Type: Journal Article
• Authors: Guo, Erliang; Guo, Lunhua; An, Changming; Zhang, Cong; Song, Kaibin; Wang, Guohui; Duan, Chunbin; Zhang, Xiwei; Yang, Xianguang; Yuan, Zhennan; Guo, Junnan; Sun, Ji; Meng, Hongxue; Chang, Rui; Li, Xiaomei; Xiu, Cheng; Mao, Xionghui; Miao, Susheng
• Is Part Of: Cancer control. Volume 27:Number 1(2020)
• Publication Date: 2020-12-08
• Subjects: laryngeal cancer -- lactate dehydrogenase -- prognosis -- overall survival -- recurrence-free survival; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Cancer -- Treatment -- Periodicals; Cancer -- Palliative treatment -- Periodicals; Cancer -- Prevention; Medical Oncology; Neoplasms -- prevention & control; Neoplasms -- therapy; Electronic journals; Periodicals; Periodicals; 616.994005
• DOI: 10.1177/1073274820978795
• Languages: English
• ISSNs: 1073-2748

Abstract

The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total of 640 resected LSCC patients were included. Preoperative lactate dehydrogenase (LDH) was assessed. Kaplan-Meier survival analysis and Cox regression analysis were conducted for overall survival (OS) and recurrence-free survival (RFS). Kaplan-Meier analysis, univariate analysis and multivariate analysis demonstrated significant prognostic value for preoperative LDH. Although LDH was predictor of OS, it failed to be a predictor of RFS. The univariate HR and 95% CI of LDH were 0.484 and 0.357-0.658 (P < 0.0001). The multivariate analysis showed that LDH (HR = 0.518, 95% CI: 0.380-0.705, p < 0.0001) was related to OS. Elevated preoperative LDH >132 IU/L was significantly associated with better survival. Preoperative LDH might be an independent prognostic marker of OS in LSCC patients undergoing surgical resection.