Gastric Signet Ring Cell Carcinoma: A Comparative Analysis of Clinicopathologic Features. (27th November 2020)

• Record Type: Journal Article
• Authors: Efared, Boubacar; Kadi, Mohamed; Tahiri, Laila; Lahmidani, Nada; Hassani, Karim Ibn Majdoub; Bouhaddouti, Hicham El; Benbrahim, Zineb; Adil, Ibrahimi Sidi; Chbani, Laila
• Is Part Of: Cancer control. Volume 27:Number 1(2020)
• Publication Date: 2020-11-27
• Subjects: gastric cancer -- signet ring cell carcinoma -- adenocarcinoma -- histopathology; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Cancer -- Treatment -- Periodicals; Cancer -- Palliative treatment -- Periodicals; Cancer -- Prevention; Medical Oncology; Neoplasms -- prevention & control; Neoplasms -- therapy; Electronic journals; Periodicals; Periodicals; 616.994005
• DOI: 10.1177/1073274820976596
• Languages: English
• ISSNs: 1073-2748

Abstract

Signet ring cell carcinoma (SRC) is a distinct histological subtype of gastric carcinoma. Our aim is to investigate differential characteristics between gastric SRC and other non SRC carcinomas (nSRC). It was a retrospective study including 183 patients diagnosed with gastric carcinoma over a period of 5 years at our pathology department. We performed statistical comparison of clinicopathological features between patients with SRC and those with nSRC. 127 patients (69.4%) had nSRC, 56 had SRC (30.6%), the mean age was 56.67 ± 14.03 years. Patients with SRC were younger than those with nSRC (mean age of 49.66 versus 59.76, P = 0.030). Patients with SRC tend to have more diffuse tumors in the stomach ( P = 0.005), with flat macroscopic appearance ( P = 0.001). Patients with SRC present more often with pT3 tumors ( P < 0.001), lymph node metastasis ( P = 0.024) and perineural invasion ( P = 0.003). There were no significant differences between SRC and nSRC in gender, vascular invasion or distant metastasis ( P > 0.05). The median survival time was 42.82 ± 1.70 months. Patients with nSRC live longer than those with SRC, but the difference was not significant ( P = 0.28). SRC is a histological subtype of gastric carcinoma with distinctive clinicopathologic features. The clinical management of patients should take into account these particular features.