Multiple environmental exposures in early-life and allergy-related outcomes in childhood. (November 2020)

• Record Type: Journal Article
• Authors: Granum, Berit; Oftedal, Bente; Agier, Lydiane; Siroux, Valerie; Bird, Philippa; Casas, Maribel; Warembourg, Charline; Wright, John; Chatzi, Leda; de Castro, Montserrat; Donaire, David; Grazuleviciene, Regina; Småstuen Haug, Line; Maitre, Lea; Robinson, Oliver; Tamayo-Uria, Ibon; Urquiza, Jose; Nieuwenhuijsen, Mark; Slama, Remy; Thomsen, Cathrine; Vrijheid, Martine
• Is Part Of: Environment international. Volume 144(2020)
• Publication Date: 2020-11
• Subjects: Exposome -- Environmental exposure -- Allergic disease -- Pregnancy -- Childhood; BiB Born in Bradford -- BMI Body mass index -- BUPA N-butyl paraben -- DAGs Directed acyclic graphs -- DEP Diethyl phthalate -- DiNP Di-iso-nonyl phthalate -- DSA Deletion-substitution-addition selection (DSA) -- EDEN Étude des Déterminants pré et postntals du development et de la santé de L'Énfant -- ExWAS Exposome-wide association study -- GAM Generalized linear models -- GLM General linear model -- HELIX The European Human Early-Life Exposome (HELIX) cohort -- INMA Infancia y Medio Ambiente -- IQR Interquartile range -- KANC Kaunus Cohort -- MEP Monoethyl phthalate -- MoBa Norwegian mother, father and childhood Study -- NO2 Nitrogen dioxide -- OR Odds ratio -- Oxo-MiNP Mono-4-methyl-7-oxooctyl phthalate -- PFHxS Perfluorohexane sulfonate -- PFOA Perfluorooctanoate -- PFOS Perfluorooctane sulfonate -- OR Particulate matter -- PMabs Particulate Matter absorbance -- RHEA RHEA Mother Child Cohort study -- VIF Variance inflation factor; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2020.106038
• Languages: English
• ISSNs: 0160-4120

Abstract

Highlights: Associations between early-life exposome and allergy-related outcomes were studied. No childhood exposures were associated with the allergy-related health outcomes. Prenatally, traffic variables, PMabs and phthalates were associated with rhinitis. Prenatally, traffic variables and phthalates were associated with itchy rash. Abstract: Introduction: Early onset and high prevalence of allergic diseases result in high individual and socio-economic burdens. Several studies provide evidence for possible effects of environmental factors on allergic diseases, but these are mainly single-exposure studies. The exposome provides a novel holistic approach by simultaneously studying a large set of exposures. The aim of the study was to evaluate the association between a broad range of prenatal and childhood environmental exposures and allergy-related outcomes in children. Material and Methods: Analyses of associations between 90 prenatal and 107 childhood exposures and allergy-related outcomes (last 12 months: rhinitis and itchy rash; ever: doctor-diagnosed eczema and food allergy) in 6–11 years old children (n = 1270) from the European Human Early-Life Exposome cohort were performed. Initially, we used an exposome-wide association study (ExWAS) considering the exposures independently, followed by a deletion-substitution-addition selection (DSA) algorithm considering all exposures simultaneously. All the exposure variables selected in the DSA were included in a final multi-exposure model using binomial general linear model (GLM). Results: In ExWAS, no exposures were associated with the outcomes after correction for multiple comparison. In multi-exposure models for prenatal exposures, lower distance of residence to nearest road and higher di- iso -nonyl phthalate level were associated with increased risk of rhinitis, and particulate matter absorbance (PMabs ) was associated with a decreased risk. Furthermore, traffic density on nearest road was associated with increased risk of itchy rash and diethyl phthalate with a reduced risk. DSA selected no associations of childhood exposures, or between prenatal exposures and eczema or food allergy. Discussion: This first comprehensive and systematic analysis of many environmental exposures suggests that prenatal exposure to traffic-related variables, PMabs and phthalates are associated with rhinitis and itchy rash.