Adverse health effects of lead exposure on physical growth, erythrocyte parameters and school performances for school-aged children in eastern China. (December 2020)

• Record Type: Journal Article
• Authors: Kuang, Wenjie; Chen, Zhaofang; Shi, Kexin; Sun, Hong; Li, Hongbo; Huang, Lei; Bi, Jun
• Is Part Of: Environment international. Volume 145(2020)
• Publication Date: 2020-12
• Subjects: Blood lead levels (BPbs) -- Erythrocyte parameters -- School performances -- Linear and non-linear regression; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2020.106130
• Languages: English
• ISSNs: 0160-4120

Abstract

Highlights: We conducted a cross-sectional study with 395 school-aged children in eastern China. Several demographic factors had significant impacts on the children's Blood lead levels (BPbs). There are dose-response relationships between BPbs and erythrocyte parameters. A significant adverse effect was from the increased BPbs on school performances. Abstract: We conducted a cross-sectional study with 395 completely matched student samples enrolled from a public primary school in Nanjing of eastern China, including questionnaires, blood samples, growth indexes and school performances, all of which were used for the analysis of variance (ANOVA) and general linear model (GLM). The results showed that factors, such as gender, age, parents' education, residential passive smoking and picky eaters, had significant impacts on the blood lead levels (BPbs). As for the linear and non-linear dose-response relationship between BPbs and erythrocyte parameters, we found a positive association between BPbs and red blood cell count (RBC count) and mean corpuscular hemoglobin concentration (MCHC) but a negative association between BPbs and hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH). When BPbs increased by 10 μg/L, the RBC count increased by 0.18 × 10 12 /L, while HGB and HCT decreased by 1.19 g/L and 0.41% for boys, respectively. As for girls, corresponding increases in RBC count was 0.05 × 10 12 /L, while HGB and HCT decreased by 0.82 g/L and 0.23%. Meanwhile, for both boys and girls, MCHC increased by 2.55 g/L, while MCV and MCH levels decreased by 0.41 fL and 0.12 pg each. Furthermore, a remarkable adverse effect ( p < 0.05) was observed on children's school performances as a result of increased BPbs. As BPbs increased by 10 μg/L, children's scores for Chinese, Math and English decreased by 0.42 points, 0.39 points and 0.87 points, respectively. In summary, our study indicated that lead exposure can have adverse health effects on children's erythrocyte parameters, BMI, and school performances.