CircRNAs in lung cancer - Biogenesis, function and clinical implication. (1st November 2020)
- Record Type:
- Journal Article
- Title:
- CircRNAs in lung cancer - Biogenesis, function and clinical implication. (1st November 2020)
- Main Title:
- CircRNAs in lung cancer - Biogenesis, function and clinical implication
- Authors:
- Wang, Chengdi
Tan, Shuangyan
Li, Jingwei
Liu, Wen-Rong
Peng, Yong
Li, Weimin - Abstract:
- Abstract: Lung cancer is the leading cause of malignancy-related incidence and mortality worldwide. Molecular mechanisms underlying tumorigenesis and development of lung cancer are still warranted to be elucidated. Previous studies have shown that non-coding RNAs are related to the tumorigenesis and progression of various cancers. However, the expression patterns and clinical implications of circRNAs in lung cancer remain obscure. CircRNAs are a special class of non-coding RNAs with stable covalently closed circular structures, high abundance and tissue/cell/development-specific expression patterns. Thus, circRNAs are a new frontier in lung cancer research. Therefore, in this review, we elucidated the biological function and mechanism of circRNAs, as well as the role of aberrant expressed circRNAs in proliferation, invasion, drug resistance and tumor microenvironment. Furthermore, we discussed that circRNAs may serve as potential clinical biomarkers for the diagnosis, prognosis and treatment of lung cancer.
- Is Part Of:
- Cancer letters. Volume 492(2020)
- Journal:
- Cancer letters
- Issue:
- Volume 492(2020)
- Issue Display:
- Volume 492, Issue 2020 (2020)
- Year:
- 2020
- Volume:
- 492
- Issue:
- 2020
- Issue Sort Value:
- 2020-0492-2020-0000
- Page Start:
- 106
- Page End:
- 115
- Publication Date:
- 2020-11-01
- Subjects:
- Lung cancer -- circRNAs -- Biological function -- Biomarkers
Cancer -- Periodicals
Neoplasms -- Periodicals
Cancer -- Périodiques
Electronic journals
616.994 - Journal URLs:
- http://www.sciencedirect.com/science/journal/03043835/ ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.canlet.2020.08.013 ↗
- Languages:
- English
- ISSNs:
- 0304-3835
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3046.485000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 14609.xml