Early-life carbamate exposure and intelligence quotient of seven-year-old children. (December 2020)

• Record Type: Journal Article
• Authors: Zhang, Jiming; Guo, Jianqiu; Wu, Chunhua; Qi, Xiaojuan; Jiang, Shuai; Zhou, Tong; Xiao, Hongxi; Li, Wenting; Lu, Dasheng; Feng, Chao; Liang, Weijiu; Chang, Xiuli; Zhang, Yubin; Cao, Yang; Wang, Guoquan; Zhou, Zhijun
• Is Part Of: Environment international. Volume 145(2020)
• Publication Date: 2020-12
• Subjects: Carbamate pesticide -- Intelligence quotient -- Exposure variation -- Birth cohort -- School-age children; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2020.106105
• Languages: English
• ISSNs: 0160-4120

Abstract

Graphical abstract: Highlights: Efficient GC–MS detection method verified rural Chinese children were widely exposed to carbamate pesticides. Evidence form prospective cohort study and multi-time-spot data enhance reliability of results. Urinary carbofuranphenol concentrations at three stages were negatively associated with children's IQ at 7 years of age. Abstract: Background: Early-life carbamate exposure during developmental period has been linked with adverse health effects and attracted attention. Methods: Three hundred and three children at age of seven were included in the current study. Urinary carbofuranphenol concentrations were measured using gas chromatography-tandem mass spectrometry. Verbal, performance and full-scale intelligence quotients (IQV, IQP, and IQFS ) were assessed using Wechsler Intelligence Scale for Children-Chinese Revised. Generalized linear models were used to explore the associations between carbofuranphenol levels and IQs. Generalized estimating equations were used to explore long-term health effect and sensitive time window. Results: Carbofuranphenol was detected in 96.6% of the seven-year-old urinary samples, the geometric mean, median, and inter quartile range of the carbofuranphenol concentrations were 0.67 μg/L, 0.30 μg/L, and 0.09–3.72 μg/L, respectively, which were similar with the level of three-year-old children from the SMBCS cohort. Seven-year-old carbofuranphenol level was negatively associated with IQP [β = −0.044; 95% confidence interval (CI): −0.087, −0.001; p = 0.045]. Three-year-old carbofuranphenol level was negatively associated with IQP (β = −0.100; 95% CI: −0.186, −0.014; p = 0.022) and IQFS (β = −0.087; 95% CI: −0.173, −0.001; p = 0.047). Carbamate exposure of maternal and children at both three and seven years old had negative associations with IQP (β = −0.089; 95% CI: −0.171, −0.007; p = 0.034), and IQFS (β = −0.064; 95% CI: −0.127, −0.000; p = 0.049) of children at age of seven. Conclusion: Results of the present study verify that children in an agricultural region of China were widely exposed to carbamate pesticides. Carbamate exposure in utero and at three and seven years may adversely impact children's neurodevelopment.