Host Polymorphisms May Impact SARS-CoV-2 Infectivity. Issue 11 (November 2020)

• Record Type: Journal Article
• Authors: Brest, Patrick; Refae, Sadal; Mograbi, Baharia; Hofman, Paul; Milano, Gerard
• Is Part Of: Trends in genetics. Volume 36:Issue 11(2020)
• Page Start: 813
• Page End: 815
• Publication Date: 2020-11
• Subjects: pharmacogenetics -- SNP -- genetic variation -- coronavirus -- infection; Genetics -- Periodicals; 576.5
• DOI: 10.1016/j.tig.2020.08.003
• Languages: English
• ISSNs: 0168-9525

Abstract

Abstract : Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected.