Management of viral hepatitis A, C, D and E in pregnancy. (October 2020)

• Record Type: Journal Article
• Authors: Seto, Mimi Tin-yan; Cheung, Ka Wang; Hung, Ivan F.N.
• Is Part Of: Best practice & research. Volume 68(2020)
• Page Start: 44
• Page End: 53
• Publication Date: 2020-10
• Subjects: Hepatitis A -- Hepatitis C -- Hepatitis D -- Hepatitis E -- Pregnancy -- Vaccination; Gynecology -- Periodicals; Obstetrics -- Periodicals; Genital Diseases, Female; Obstetrics; Gynecology; Obstetrics; Periodicals; 618.05
• DOI: 10.1016/j.bpobgyn.2020.03.009
• Languages: English
• ISSNs: 1521-6934

Abstract

Abstract: Viral hepatitis can cause significant maternal and neonatal morbidity and mortality. Hepatitis A and E mainly present as acute hepatitis during pregnancy, while hepatitis C and D are usually found as chronic infection in pregnant women. Hepatitis A remains self-limiting during pregnancy while hepatitis E has a higher prevalence and manifests with a rigorous course in pregnant women. Screening of hepatitis C during pregnancy and its subsequent management during pregnancy are still a debatable topic. New treatments of hepatitis C and E require further evaluation for use in pregnancy. This review summarizes the prevalence, clinical manifestations, maternal, foetal and neonatal effects, and the management of hepatitis A, C, D and E viral infection during pregnancy. Highlights: Viral hepatitis infection during pregnancy is not uncommon. Vertical transmission of hepatitis A, C, D and E is possible. Treatment of acute hepatitis during pregnancy remains supportive. Extensive research is needed on direct-acting antivirals during pregnancy and lactation. Breastfeeding should be encouraged for women infected with hepatitis A, C and D.