Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring. (November 2020)

• Record Type: Journal Article
• Authors: Mustieles, Vicente; D'Cruz, Shereen Cynthia; Couderq, Stephan; Rodríguez-Carrillo, Andrea; Fini, Jean-Baptiste; Hofer, Tim; Steffensen, Inger-Lise; Dirven, Hubert; Barouki, Robert; Olea, Nicolás; Fernández, Mariana F.; David, Arthur
• Is Part Of: Environment international. Volume 144(2020)
• Publication Date: 2020-11
• Subjects: Bisphenol A -- Bisphenol analogues -- Human biomonitoring -- Effect biomarker -- Adverse outcome pathway; AO adverse outcome -- AOP adverse outcome pathway -- ACR albumin-to-creatinine ratio -- AD androstenedione -- AhR aryl hydrocarbon receptor -- ALT alanine aminotransferase -- AMH anti-Müllerian hormone -- AP alkaline phosphatase -- AR androgen receptor -- AST aspartate aminotransferase -- BEX2 brain expressed X-linked 2 -- BDNF brain-derived neurotrophic factor -- BPA bisphenol A -- BRCA1 breast cancer 1 -- CaMKII calcium/calmodulin-dependent kinase II -- CMHS Canadian measures health survey -- COMT catechol O-methyltransferase -- CpG 5′—cytosine—phosphate—guanine—3′ -- CREB cAMP response element-binding protein -- CRP c-reactive protein -- DHEA-S dehydroepiandrosterone sulfate -- DHT dihydrotestosterone -- DNA deoxyribonucleic acid -- E1 estrone -- E2 17β-estradiol -- E3 estriol -- EDCs endocrine-disrupting chemicals -- ERR estrogen related receptor -- ER estrogen receptor -- FAI free androgen index -- FSH follicle stimulating hormone -- FT free testosterone -- FT3 free triiodothyronine -- FT4 free thyroxine -- GDNF glial cell-derived neurotrophic factor -- GnRH gonadotrophin releasing hormone -- GGT gamma glutamyl transpeptidase -- GSH glutathione, reduced form -- HbA1c glycated hemoglobin -- HBM human biomonitoring -- HBM4EU European Human Biomonitoring Initiative -- HDL-C high-density lipoprotein cholesterol -- HNE-MA 4-hydroxy-2-nonenal-mercapturic acid -- HOXA10 homeobox A10 -- HOMA-B homeostasis model assessment of beta-cell function -- HOMA-IR homeostasis model assessment for insulin resistance -- HP hypothalamus-pituitary -- HPA hypothalamus–pituitaryadrenal -- HPLC high performance liquid chromatography -- HPT hypothalamus-pituitary-thyroid -- hs-CRP high-sensitivity c-reactive protein -- IgE immunoglobulin E -- IL interleukin -- INHB inhibin B -- INSL3 insulin-like peptide 3 -- KE key event -- KiSS kisspeptin -- LD lactate dehydrogenase -- LDL-C low-density lipoprotein cholesterol -- LH luteinizing hormone -- LINE-1 long interspersed element-1 -- LTP long-term potentiation -- LTRs long terminal repeats -- MDA malondialdehyde -- MIE molecular initiating event -- MoA mode of action -- NHANES National Health and Nutrition Examination Survey -- NIS sodium/iodide symporter -- NMDARs glutamate N-methyl-D-aspartate receptors -- NRs nuclear receptors -- NRC National Research Council -- PCOS polycystic ovary syndrome -- PlGF placental growth factor -- PBMCs peripheral blood mononuclear cells -- PREG pregnenolone -- PRL prolactin -- PXR pregnane X receptor -- P4 progesterone -- RHs reproductive hormones -- RNA ribonucleic acid -- ROS reactive oxygen species -- sFlt1 soluble fms-like tyrosine kinase-1 -- SHBG sex hormone-binding globulin -- SP4 specific protein 4 -- STAT3 signal transducer and activator of transcription 3 -- SULT2A1 sulfotransferase family 2A member 1 -- TBA2-MDA thiobarbituric acid-malondialdehyde -- TC total cholesterol -- TG triglycerides -- THs thyroid hormones -- TNF-α tumor necrosis factor alpha -- TPOab thyroid peroxidase autoantibodies -- TSH thyroid-stimulating hormone -- TSLP thymic stromal lymphopoietin -- TSP50 testis-specific protease-like protein 50 -- TT total testosterone -- TT3 total triiodothyronine -- TT4 total thyroxine -- T2DM type 2 diabetes mellitus -- U.S. the United States of America -- WHO World Health Organization -- 8OHdG 8-hydroxy-2′-deoxyguanosine -- 8-isoprostane 8-iso-prostaglandin F2α; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2020.105811
• Languages: English
• ISSNs: 0160-4120

Abstract

Highlights: This review identified and prioritized existing effect biomarkers for bisphenols. 119 epidemiologic studies were selected, analyzed, tabulated and discussed. An inventory of molecular and biochemical effect biomarkers was created. BDNF, kisspeptin and gene expression of nuclear receptors were prioritized. Adverse outcome pathway (AOP) data was gathered to cover knowledge gaps. Abstract: Human biomonitoring (HBM) studies have demonstrated widespread and daily exposure to bisphenol A (BPA). Moreover, BPA structural analogues (e.g. BPS, BPF, BPAF), used as BPA replacements, are being increasingly detected in human biological matrices. BPA and some of its analogues are classified as endocrine disruptors suspected of contributing to adverse health outcomes such as altered reproduction and neurodevelopment, obesity, and metabolic disorders among other developmental and chronic impairments. One of the aims of the H2020 European Human Biomonitoring Initiative (HBM4EU) is the implementation of effect biomarkers at large scales in future HBM studies in a systematic and standardized way, in order to complement exposure data with mechanistically-based biomarkers of early adverse effects. This review aimed to identify and prioritize existing biomarkers of effect for BPA, as well as to provide relevant mechanistic and adverse outcome pathway (AOP) information in order to cover knowledge gaps and better interpret effect biomarker data. A comprehensive literature search was performed in PubMed to identify all the epidemiologic studies published in the last 10 years addressing the potential relationship between bisphenols exposure and alterations in biological parameters. A total of 5716 references were screened, out of which, 119 full-text articles were analyzed and tabulated in detail. This work provides first an overview of all epigenetics, gene transcription, oxidative stress, reproductive, glucocorticoid and thyroid hormones, metabolic and allergy/immune biomarkers previously studied. Then, promising effect biomarkers related to altered neurodevelopmental and reproductive outcomes including brain-derived neurotrophic factor (BDNF), kisspeptin (KiSS), and gene expression of nuclear receptors are prioritized, providing mechanistic insights based on in vitro, animal studies and AOP information. Finally, the potential of omics technologies for biomarker discovery and its implications for risk assessment are discussed. To the best of our knowledge, this is the first effort to comprehensively identify bisphenol-related biomarkers of effect for HBM purposes.