The microRNA-424/503 cluster: A master regulator of tumorigenesis and tumor progression with paradoxical roles in cancer. (1st December 2020)

• Record Type: Journal Article
• Authors: Wu, Ye; Wang, Wei; Yang, An-Gang; Zhang, Rui
• Is Part Of: Cancer letters. Volume 494(2020)
• Page Start: 58
• Page End: 72
• Publication Date: 2020-12-01
• Subjects: miR-424/503 cluster -- Tumor-suppressive miRNA -- oncomiR -- Coordinating regulation; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2020.08.027
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: MicroRNAs (miRNAs) are a group of non-coding RNAs that play a crucial role in post-transcriptional gene regulation and act as indispensable mediators in several critical biological processes, including tumorigenesis, tissue homeostasis, and regeneration. MiR-424 and miR-503 are intragenic miRNAs that are clustered on human chromosome Xq26.3. Previous studies have reported that both miRNAs are dysregulated and play crucial but paradoxical roles in tumor initiation and progression, involving different target genes and molecular pathways. Moreover, these two miRNAs are concomitantly expressed in several cancer cells, indicating a coordinating function as a cluster. In this review, the roles and regulatory mechanisms of miR-424, miR-503, and miR-424/503 cluster are summarized in different types of cancers. Highlights: The cluster-based expression is one of the characteristics of miRNAs and regulates target genes in a coordinative manner. The miR-424/503 cluster is dysregulated and plays crucial but paradoxical roles in tumor initiation and progression. The roles, regulatory mechanisms, and functioning rules of the miR-424/503 cluster and individual members are summarized. It aimes to provide insights and guidance for the development of tumor-specific therapeutics targeting this cluster.