Changes in cognitive function after resection of lesions in the anterior part of the lateral ventricle via an interhemispheric transcallosal approach. (September 2020)

• Record Type: Journal Article
• Authors: Nakajo, Kosuke; Uda, Takehiro; Goto, Takeo; Morisako, Hiroki; Nishijima, Shugo; Kawashima, Toshiyuki; Tanoue, Yuta; Nagahama, Atsufumi; Sasaki, Tsuyoshi; Ko, Saya; Ohata, Kenji
• Is Part Of: Journal of clinical neuroscience. Volume 79(2020)
• Page Start: 39
• Page End: 44
• Publication Date: 2020-09
• Subjects: IHTCA interhemispheric transcallosal approach -- EOR extent of resection -- MMSE Mini-Mental State Examination -- WAIS-III Third-version Wechsler Adult Intelligence Scale -- WMS-R Wechsler Memory Scale-Revised; Cognitive function -- Intraventricular tumor -- Anterior interhemispheric transcallosal approach -- Callosotomy; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2020.07.026
• Languages: English
• ISSNs: 0967-5868

Abstract

Abstract: Anterior callosotomy to about 20 mm has been considered relatively safe empirically. The present study aimed to compare cognitive function before and after resection of tumors in the anterior part of the lateral ventricle. We analyzed 6 patients with intraventricular tumors located in the anterior horn or body of the lateral ventricle who underwent surgical excision via interhemispheric transcallosal approach at Osaka City University Hospital between March 2015 and August 2018. And clinical and imaging studies, neuropsychological function using MMSE, WAIS-III and WMS-R and surgical complications were retrospectively reviewed based on the medical records at our institution. As a result, 4 patients achieved gross total resection of the tumor and 2 patients achieved subtotal resection. 4 patients showed hydrocephalus, which disappeared in each case within 6 months after tumor resection. Mean length of callosotomy was 16.9 mm (range, 15.5–26.1 mm). One patient showed postoperative transient deficits including aphasia, microphonia, ballism in all extremities and hemiplegia, and another patient experienced subjective difficulty when talking. These symptoms disappeared within 3 months after tumor resection. Scores from the MMSE and WAIS-III showed no significant postoperative deterioration. Performance intelligence quotient (P = 0.04), full intelligence quotient (P = 0.04) and perceptual organization (P = 0.03) of WAIS-III were significantly improved after surgery compared with preoperatively. In conclusion, anterior corpus callosotomy of about 20 mm for intraventricular tumor in the anterior horn or body of the lateral ventricle might have little effect on cognitive function in the chronic phase, although the influence of hydrocephalus cannot be ignored.