Atomic layer deposition of γ-Fe2O3 nanoparticles on multi-wall carbon nanotubes for magnetic drug delivery and liver cancer treatment. Issue 17 (1st December 2020)

• Record Type: Journal Article
• Authors: Ge, Xiaofen; Fu, Meili; Niu, Xing; Kong, Xiaoxiao
• Is Part Of: Ceramics international. Volume 46:Issue 17(2020)
• Page Start: 26557
• Page End: 26563
• Publication Date: 2020-12-01
• Subjects: Multi-wall carbon nanotubes (MWCNTs) -- Surface modification -- Drug delivery -- Atomic layer deposition -- Drug release -- Cytotoxicity; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2020.07.123
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: Multi-wall carbon nanotubes (MWCNTs) were oxidized by a mixed acid (HNO3 /H2 SO4 ), following by γ-Fe2 O3 nanoparticle deposition by Atomic Layer Deposition (ALD). After that, the surface was further modified for doxorubicin (DOX) drug loading. The morphology and the surface functional groups of MWCNTs were determined by TEM and FTIR, and the DOX loading on the drug carriers was determined by UV–Vis spectroscopy. The N2 adsorption/desorption curves illustrated that the γ-Fe2 O3 deposition had little impact on the specific surface area of MWCNTs. Finally, the cytotoxicity of MWCNTs and MWCNTs/γ-Fe2 O3 based drug carriers was investigated and compared. The results showed that γ-Fe2 O3 had negligible impacts on the DOX release from MWCNTs, but its magnetization could be beneficial to the precise magnetic drug delivery.