Concurrent use of aspirin with osimertinib is associated with improved survival in advanced EGFR-mutant non-small cell lung cancer. (November 2020)

• Record Type: Journal Article
• Authors: Liu, Xiaoke; Hong, Lingzhi; Nilsson, Monique; Hubert, Shawna Marie; Wu, Shuhong; Rinsurongkawong, Waree; Lewis, Jeffery; Spelman, Amy; Roth, Jack; Swisher, Steven; He, Yong; Jack Lee, J.; Fang, Bingliang; Heymach, John V.; Zhang, Jianjun; Le, Xiuning
• Is Part Of: Lung cancer. Volume 149(2020)
• Page Start: 33
• Page End: 40
• Publication Date: 2020-11
• Subjects: NSCLC non-small cell lung cancer -- PFS progression-free survival -- OS overall survival -- NR Not reached -- CNS central nervous system -- TKIs tyrosine kinase inhibitors -- COX nonselective cyclooxygenase -- ORR objective response rate -- EMT epithelial-to-mesenchymal transition -- PGE2 prostaglandin E2; Non-small cell lung cancer -- Aspirin -- Osimertinib -- EGFR -- TP53 -- PD-L1; Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2020.08.023
• Languages: English
• ISSNs: 0169-5002

Abstract

Highlights: Concurrent aspirin use with osimertinib in EGFR -mutant NSCLC patients was associated with improved PFS. The benefit is independent of lines of therapy, CNS metastasis, EGFR mutation type, TP53 status, PD-L1 status, age or gender. With aspirin use, the progression-free survival in L858R patients are similar to the EGFR 19Del patients. Abstract: Background: Osimertinib is the treatment of choice for advanced EGFR -mutant non-small cell lung cancer (NSCLC). However, novel strategies to improve the duration of disease control are still urgently needed. Aspirin has been shown to decrease cancer incidence and improve outcomes in various malignancies. Therefore, we evaluated a cohort of patients who received osimertinib with or without concurrent use of aspirin to assess whether the addition of aspirin may lead to improved clinical outcomes. Methods: MD Anderson Cancer Center GEMINI database was retrospectively queried for EGFR -mutant NSCLC patients who received osimertinib with or without concurrent use of aspirin for progression-free survival (PFS) and overall survival (OS). Results: A total of 365 patients were identified including 77 which had concurrent use of aspirin. Patients in the aspirin-osimertinib group had significantly improved PFS (21.3 vs 11.6 months; HR, 0.52; 95 % CI, 0.38−0.70) and OS (Not reached vs 32.3 months; HR, 0.56; 95 % CI, 0.35−0.91) compared to osimertinib group. In subgroup analyses, the aspirin-associated PFS benefit was observed in patients with and without central nervous system (CNS) metastases, as well as in osimertinib first-line setting and in subsequent line setting. The median PFS in EGFR 19Del patients was longer than EGFR L858R patients with osimertinib, and when aspirin was added, the median PFS significantly improved in both groups regardless of lines of therapy. The benefit from aspirin was independent of age, gender, TP53 mutational status, or PD-L1 positivity. Conclusion: Concurrent aspirin use with osimertinib in EGFR -mutant NSCLC patients was associated with improved survival, regardless of lines of therapy, CNS metastatic status, EGFR mutation type, age, gender, TP53, and PD-L1 status.