Intention to participate in a COVID-19 vaccine clinical trial and to get vaccinated against COVID-19 in France during the pandemic. Issue 45 (21st October 2020)

• Record Type: Journal Article
• Authors: Detoc, Maëlle; Bruel, Sébastien; Frappe, Paul; Tardy, Bernard; Botelho-Nevers, Elisabeth; Gagneux-Brunon, Amandine
• Is Part Of: Vaccine. Volume 38:Issue 45(2020)
• Page Start: 7002
• Page End: 7006
• Publication Date: 2020-10-21
• Subjects: COVID-19 -- Vaccine -- Vaccine hesitancy -- Pandemics -- SARS-CoV-2; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2020.09.041
• Languages: English
• ISSNs: 0264-410X

Abstract

Highlights: Nearly 75% of the respondents indicated that they might get COVID-19 vaccine. 48% of the respondents may accept to participate in a COVID-19 vaccine clinical trial. Healthcare workers were more prone to get vaccinated against COVID-19 than non HCWs. Abstract: Introduction: The world is facing the COVID-19 pandemic. The development of a vaccine is challenging. We aimed to determine the proportion of people who intend to get vaccinated against COVID-19 in France or to participate in a vaccine clinical trial. Methods: We conducted an anonymous on-line survey from the 26th of March to the 20th of April 2020. Primary endpoints were the intention to get vaccinated against COVID-19 if a vaccine was available or participate in a vaccine clinical trial. Results: Three thousand two hundred and fifty nine individuals answered the survey; women accounted for 67.4% of the respondents. According to their statements, 2.512 participants (77.6%, 95% CI 76.2–79%) will certainly or probably agree to get vaccinated against COVID-19. Older age, male gender, fear about COVID-19, being a healthcare worker and individual perceived risk were associated with COVID-19 vaccine acceptance. Vaccine hesitancy was associated with a decrease in COVID-19 vaccine acceptance. One thousand and five hundred and fifty respondents (47.6% 95% CI 45.9–49.3%) will certainly or probably agree to participate in a COVID-19 vaccine clinical trial. Older age, male gender, being a healthcare worker and individual perceived risk were associated with potential acceptance to participate in a COVID-19 vaccine clinical trial. Vaccine hesitancy was associated with refusal for participation in a COVID-19 vaccine clinical trial. Conclusions: Nearly 75% and 48% of the survey respondents were respectively likely to accept vaccination or participation in a clinical trial against COVID-19. Vaccine hesitancy will be the major barrier to COVID-19 vaccine uptake.