Primary central nervous system T-cell lymphoma: An analysis from the surveillance, epidemiology, and end results program. (September 2020)

• Record Type: Journal Article
• Authors: Long, Hao; Li, Siyi; Zhang, Yuzhen; Li, Ruqi; Fong, Tszhei; Yang, Chen; Wang, Hai; Xu, Nan; Xu, Yuan; Wang, Kewan; Yang, Kaijun; Qi, Songtao; Wang, Jun
• Is Part Of: Journal of clinical neuroscience. Volume 79(2020)
• Page Start: 74
• Page End: 79
• Publication Date: 2020-09
• Subjects: CI Confidence interval -- CNS Central nervous system -- DLBCL Diffuse large B-cell lymphoma -- HR Hazard ratio -- ICD-O-3 International Classification of Diseases for Oncology, Third Edition -- NOS Not otherwise specified -- OS Overall survival -- PCNSL Primary central nervous system lymphoma -- PCNSBCL Primary central nervous system B-cell lymphoma -- PCNSTCL Primary central nervous system T-cell lymphoma -- SD Standard deviation -- SE Standard error -- SEER Surveillance, Epidemiology, and End Results; Primary central nervous system T-cell lymphoma -- PCNSTCL -- SEER; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2020.07.020
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: PCNSTCL is a rare neoplasm with poor prognosis. Slightly higher incidence in males. Patients with PCNSTCL aged younger than 60 experienced better prognosis. Abstract: Background: Primary central nervous system T-cell lymphoma (PCNSTCL) is a rare neoplasm with few data regarding its common features and survival characteristics. Objective: To explore the Surveillance, Epidemiology, and End Results 18 (SEER 18) database to determine the epidemiology of PCNSTCL. Methods: The SEER 18 registry database was queried to identify patients diagnosed with PCNSTCL from 1973 to 2014 and extract their information. Age-specific rates and Kaplan-Meier overall survival (OS) were calculated. A Cox proportional hazards model was applied to investigate relationships between various demographic/treatment variables and OS. Results: The age-specific incidence rates were higher in the older population (≥60 years). Among 59 PCNSTCL cases from the SEER 18, the mean age at presentation was 55.8 years (SD, ±17.95), with a male predominance (1.36:1.00). The median follow-up was 8 months, and the median OS was 8 months (SE, ±4.162). The 1-, 3-, and 5-year OS was 46.3% [95% CI, 33.4%–59.2%], 32.8% [20.3%–45.3%], and 32.8% [20.3%–45.3%], respectively. Seventeen of the 59 patients survived at last follow-up. Patients < 60 years had a greater 3-year OS compared with patients ≥ 60 years (52.6% [33.6%–71.6%] vs 13.9% [1.4%–26.4%]. Multivariate analysis has demonstrated that only age at diagnosis (≥60/<60 years) exhibited a significant relationship with OS (HR, 3.495 [1.688–7.235]; p = 0.001). Sex (female/male) was observed to have a doubted trend towards significance (HR, 0.487 [0.231–1.030]; p = 0.060). Conclusions: PCNSTCL is generally of poor prognosis but younger age at diagnosis (<60 years) predicts a better prognosis.