Approach to critical illness myopathy and polyneuropathy in the older SARS-CoV-2 patients. (September 2020)

• Record Type: Journal Article
• Authors: McClafferty, Brendan; Umer, Ibrahim; Fye, Gary; Kepko, Douglas; Kalayanamitra, Ricci; Shahid, Zainab; Ramgobin, Devyani; Cai, Alice; Groff, Andrew; Bhandari, Abani; Aggarwal, Chander Shekher; Patel, Ravi; Bhatt, Dhirisha; Polimera, Hyma; Sahu, Nitasa; Vunnam, Ramarao; Golamari, Reshma; Kumar, Ashutosh; Jain, Rohit
• Is Part Of: Journal of clinical neuroscience. Volume 79(2020)
• Page Start: 241
• Page End: 245
• Publication Date: 2020-09
• Subjects: CIM critical illness myopathy -- CIP critical illness polyneuropathy -- CIPNM critical illness polyneuromyopathy -- PCIS post intensive care syndrome -- ANM acute necrotizing myopathy -- (IL-6) interleukin-6 -- SAA1 serum amyloid A1 -- ICUAW ICU-acquired weakness -- ARDS acute respiratory distress syndrome; SARS-CoV-2 -- COVID-19 -- Critical illness myopathy -- Critical illness polyneuropathy -- Intensive care unit-acquired weakness -- Older adults; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2020.07.058
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Critical illness myopathy/neuropathy often go under-diagnosed. Over 70% of patients hospitalized for SARS-CoV-2 were ≥50 years old. Older populations are at higher risk of suffering from ICU acquired weakness. Early mobilization is a mainstay of treatment for ICU acquired weakness. Abstract: One of the major concerns of the health care community and the public surrounding the SARS-CoV-2 pandemic is the availability and use of ventilators. Unprecedented surges of patients presented to intensive care units across the country, with older adults making up a large proportion of the patient population. This paper illustrates contemporary approaches to critical illness myopathy (CIM), critical illness polyneuropathy (CIP), and critical illness polyneuromyopathy (CIPNM) in older patients, including incidence, risk factors, mechanisms for pathology, diagnosis, contemporary treatment approaches, and outcomes. We hope that the following analysis may help educate clinicians and ultimately decrease the duration of the mechanical ventilation required by these patients, resulting in improved clinical outcomes and an increase in ventilator availability for other patients in need.