Proteoglycan signaling in tumor angiogenesis and endothelial cell autophagy. (May 2020)

• Record Type: Journal Article
• Authors: Gubbiotti, Maria A.; Buraschi, Simone; Kapoor, Aastha; Iozzo, Renato V.
• Is Part Of: Seminars in cancer biology. Volume 62(2020)
• Page Start: 1
• Page End: 8
• Publication Date: 2020-05
• Subjects: AMPK adenosine monophosphate kinase -- BGN biglycan -- DCN decorin -- EGFR epidermal growth factor receptor -- ERK extracellular signal-regulated kinase -- GSC glioma stem cells -- Hspg heparan sulfate proteoglycan -- LC3 microtubule-associated light chain protein 3 -- LG3 laminin globular domain 3 -- Met hepatocyte growth factor or scatter factor receptor -- mTOR mammalian target of rapamycin -- NF-кb nuclear factor kappa-light-chain-enhancer of activated B cells -- PEG3 paternally expressed gene 3 -- PGC1-α peroxisome proliferator-activated receptor gamma co-activator 1α -- RTK Receptor Tyrosine Kinase -- SDCBP syndecan binding protein -- TAM tumor-associated macrophage -- TLR Toll-like receptor -- VEGF-A vascular endothelial cell growth factor A -- VEGFR2 vascular endothelial cell growth factor receptor 2; Proteoglycan -- Autophagy -- Angiogenesis -- Decorin -- Perlecan -- Biglycan -- Endostatin -- Tumorigenesis; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2019.05.003
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: The need for more effective cancer therapies is omnipresent as the ever-complex, and highly adaptive, mechanisms of tumor biology allow this disease to elude even the most stringent treatment options. The expanding field of proteoglycan signaling is enticing as a reservoir of potential drug targets and prospects for novel therapeutic strategies. The newest trend in proteoglycan biology is the interplay between extracellular signaling and autophagy fueled by the close link between autophagy and angiogenesis. Here we summarize the most current evidence surrounding proteoglycan signaling in both of these biological processes featuring the well-known suspects, decorin and perlecan, as well as other up-and-coming neophytes in this evolving signaling web.