Development and validation of autophagy‐related‐gene biomarker and nomogram for predicting the survival of cutaneous melanoma. Issue 7 (21st February 2020)

• Record Type: Journal Article
• Authors: Wan, Qi; Jin, Lin; Su, Yaru; liu, Ying; Li, Chaoyang; Wang, Zhichong
• Is Part Of: IUBMB life. Volume 72:Issue 7(2020)
• Page Start: 1364
• Page End: 1378
• Publication Date: 2020-02-21
• Subjects: differentially expressed autophagy‐related genes -- melanoma -- nomogram -- prognostic biomarker; Biochemistry -- Periodicals; Molecular biology -- Periodicals; 572.8
• DOI: 10.1002/iub.2258
• Languages: English
• ISSNs: 1521-6543

Abstract

Abstract: Autophagy plays a critical role in cutaneous melanoma, but the prognostic research of differentially expressed autophagy‐related genes (DEARGs) in melanoma is lacking. Therefore, autophagy‐related gene expression data of 630 melanoma patients were obtained from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas database. The DEARGs were identified by "limma" package in R software. Best survival analysis and the least absolute shrinkage and selection operator method were performed to identify a robust 7‐DEARG signature as well as construct nomogram associated with the clinical characteristics and validation in internal and external sets. This 7‐DEARG signature could be regarded as an independent prognostic signature in clinical setting, and nomogram may supply a more simple and accurate prediction for the prognosis of melanoma. Moreover, 5 cancer hallmarks and 18 potential compounds are commonly enriched in high‐risk expression phenotype. Thus, our finding provides new clinical evidences for the accurate diagnosis and identifies a potential prognostic autophagy‐related marker for the treatment of melanoma.