Olfactory identification in subjective cognitive decline and mild cognitive impairment: Association with tau but not amyloid positron emission tomography. Issue 1 (23rd September 2017)

• Record Type: Journal Article
• Authors: Risacher, Shannon L.; Tallman, Eileen F.; West, John D.; Yoder, Karmen K.; Hutchins, Gary D.; Fletcher, James W.; Gao, Sujuan; Kareken, David A.; Farlow, Martin R.; Apostolova, Liana G.; Saykin, Andrew J.
• Is Part Of: Alzheimer's & dementia. Volume 9:Issue 1(2017)
• Page Start: 57
• Page End: 66
• Publication Date: 2017-09-23
• Subjects: Olfaction -- Alzheimer's disease -- [18F]Flortaucipir (AV‐1451) -- Tau -- Neurodegeneration; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1016/j.dadm.2017.09.001
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: We investigated the association between olfactory identification and Alzheimer's disease biomarkers, including amyloid, tau, and neurodegeneration. Methods: Thirty‐four older adults, including 19 cognitively normal (CN), 10 subjective cognitive decline (SCD), and 5 mild cognitive impairment, underwent amyloid positron emission tomography, magnetic resonance imaging, and the University of Pennsylvania Smell Identification Test (UPSIT). Twenty‐six also underwent tau positron emission tomography. Associations between the UPSIT and regionally sampled amyloid, tau, and temporal atrophy were evaluated. Voxel‐wise regression models were also utilized. Analyses were conducted with the full sample and only CN/SCD. Results: Lower UPSIT scores were associated with increased temporal and parietal tau burden in regional and voxel‐wise analyses in the full sample and in CN and SCD only. Temporal lobe atrophy was associated with lower UPSIT score. Amyloid was not associated with the UPSIT. Discussion: Impairment on the UPSIT may be a good marker for tau and neurodegeneration in preclinical or prodromal Alzheimer's disease.