Polyhydrazide‐Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels. (4th February 2020)

• Record Type: Journal Article
• Authors: Roy, Arundhati; Joshi, Himanshu; Ye, Ruijuan; Shen, Jie; Chen, Feng; Aksimentiev, Aleksei; Zeng, Huaqiang
• Is Part Of: Angewandte Chemie. Volume 132:Number 12(2020)
• Page Start: 4836
• Page End: 4843
• Publication Date: 2020-02-04
• Subjects: Wasserstoffbrücken -- Ionenkanäle -- Iodid -- Moleküldynamik -- Supramolekulare Chemie; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201916287
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Reported herein is a series of pore‐containing polymeric nanotubes based on a hydrogen‐bonded hydrazide backbone. Nanotubes of suitable lengths, possessing a hollow cavity of about a 6.5 Å diameter, mediate highly efficient transport of diverse types of anions, rather than cations, across lipid membranes. The reported polymer channel, having an average molecular weight of 18.2 kDa and 3.6 nm in helical height, exhibits the highest anion‐transport activities for iodide ( EC 50 =0.042 μm or 0.028 mol % relative to lipid), whcih is transported 10 times more efficiently than chlorides ( EC 50 =0.47 μm ). Notably, even in cholesterol‐rich environment, iodide transport activity remains high with an EC 50 of 0.37 μm . Molecular dynamics simulation studies confirm that the channel is highly selective for anions and that such anion selectivity arises from a positive electrostatic potential of the central lumen rendered by the interior‐pointing methyl groups. Abstract : Eine neue Klasse Foldamer‐basierter porenbildender helikal gefalteter Polyhydrazide mit hydrophoben Hohlräumen von 6.5 Å Durchmesser vermittelt den Membrantransport von Anionen, nicht von Kationen. Der beste Kanal, mit einer 3.6 nm hohen Helix, zeigt die höchste bekannte Iodidtransportaktivität (EC50 =0.042 μm oder 0.028 Mol‐% bezogen auf das Lipid) und eine hohe I − /Cl − ‐Selektivität von 11 bezogen auf den EC50 ‐Wert bzw. 42 bezogen auf die Anfangsgeschwindigkeitskonstanten.