Front Cover: Engineering of Laccase CueO for Improved Electron Transfer in Bioelectrocatalysis by Semi‐Rational Design (Chem. Eur. J. 22/2020). Issue 22 (16th April 2020)

• Record Type: Journal Article
• Authors: Zhang, Lingling; Cui, Haiyang; Dhoke, Gaurao V.; Zou, Zhi; Sauer, Daniel F.; Davari, Mehdi D.; Schwaneberg, Ulrich
• Is Part Of: Chemistry. Volume 26:Issue 22(2020)
• Page Start: 4880
• Page End: 4880
• Publication Date: 2020-04-16
• Subjects: bioelectrocatalysis -- copper efflux oxidase -- electron transfer -- oxygen reduction reaction -- site-saturation mutagenesis; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202001026
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Copper efflux oxidase (CueO) from Escherichia coli is a special bacterial laccase due to its fifth copper binding site. In contrast with previous reports, this work illustrates the relationship between the fifth copper region and electrocatalytic properties. Through a semi‐rational design, an increase in localized structural stability and a decrease of electron transfer pathway are found to contribute to beneficial CueO variants. It may give clues on how to tailor laccases or other oxidoreductases for bioelectrocatalytic applications. More information can be found in the Full Paper by L. Zhang, U. Schwaneberg, et al. on page 4974 .