Donor acute kidney injury and its effect on 1‐year post‐transplant kidney allograft fibrosis. Issue 2 (11th February 2020)

• Record Type: Journal Article
• Authors: van der Windt, Dirk J.; Mehta, Rajil; Jorgensen, Dana R.; Bou‐Samra, Patrick; Hariharan, Sundaram; Randhawa, Parmjeet S.; Sood, Puneet; Molinari, Michele; Wijkstrom, Martin; Ganoza, Armando; Tevar, Amit D.
• Is Part Of: Clinical transplantation. Volume 34:Issue 2(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-11
• Subjects: acute kidney injury -- cadaveric renal transplant -- delayed graft function -- extended criteria -- interstitial fibrosis -- KDPI; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.13770
• Languages: English
• ISSNs: 0902-0063

Abstract

Abstract: Transplantation of kidneys from deceased donors with acute kidney injury (AKI) can expand the donor pool. We investigated the effect of donor AKI on renal function and chronic changes on protocol biopsies at 1‐year post‐transplant. Donor AKI was defined according to Acute Kidney Injury Network (AKIN) criteria. Between 2013 and 2017, 333 kidneys were transplanted and subsequently biopsied after 1 year. Fifty‐three kidneys from AKI donors (AKIN stage I n = 42, stage II n = 8, stage III n = 3) were compared to 280 kidneys from non‐AKI donors. At 1‐year follow‐up, patient and graft survival were comparable. Donor AKI was not predictive of IFTA (Banff interstitial fibrosis plus tubular atrophy scores) at 1‐year post‐transplant biopsy (2.10 ± 1.28 in AKI, 2.09 ± 1.22 in non‐AKI, P = .95). Donor AKI was also not associated with progression of IFTA from 3 to 12 months ( P = .69), or inferior glomerular filtration rate (eGFR, P = .94). In a multivariate analysis, the odds of IFTA >2 were comparable between AKI and non‐AKI groups. In conclusion, the transplantation of kidneys from donors with predominantly stage I AKI results in comparable function and degree of fibrosis on protocol biopsies 1‐year post‐transplant. Selected grafts from donors with AKI are a valuable tool for expanding the donor pool for kidney transplantation.