A probabilistic approach to assess antibiotic resistance development risks in environmental compartments and its application to an intensive aquaculture production scenario. (December 2017)

• Record Type: Journal Article
• Authors: Rico, Andreu; Jacobs, Rianne; Van den Brink, Paul J.; Tello, Alfredo
• Is Part Of: Environmental pollution. Volume 231:Part 1(2017)
• Page Start: 918
• Page End: 928
• Publication Date: 2017-12
• Subjects: Antibiotics -- Antibiotic resistance -- Risk assessment -- Environment -- Aquaculture; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2017.08.079
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Estimating antibiotic pollution and antibiotic resistance development risks in environmental compartments is important to design management strategies that advance our stewardship of antibiotics. In this study we propose a modelling approach to estimate the risk of antibiotic resistance development in environmental compartments and demonstrate its application in aquaculture production systems. We modelled exposure concentrations for 12 antibiotics used in Vietnamese Pangasius catfish production using the ERA-AQUA model. Minimum selective concentration (MSC) distributions that characterize the selective pressure of antibiotics on bacterial communities were derived from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) Minimum Inhibitory Concentration dataset. The antibiotic resistance development risk (RDR) for each antibiotic was calculated as the probability that the antibiotic exposure distribution exceeds the MSC distribution representing the bacterial community. RDRs in pond sediments were nearly 100% for all antibiotics. Median RDR values in pond water were high for the majority of the antibiotics, with rifampicin, levofloxacin and ampicillin having highest values. In the effluent mixing area, RDRs were low for most antibiotics, with the exception of amoxicillin, ampicillin and trimethoprim, which presented moderate risks, and rifampicin and levofloxacin, which presented high risks. The RDR provides an efficient means to benchmark multiple antibiotics and treatment regimes in the initial phase of a risk assessment with regards to their potential to develop resistance in different environmental compartments, and can be used to derive resistance threshold concentrations. Graphical abstract: Highlights: A modelling approach is proposed to assess antibiotic resistance development risks. The approach is grounded on probabilistic risk assessment theory. It was applied to assess resistance development in pond aquaculture environments. The study shows that pond sediments are hot-spots for resistance development. The modelling approach can be used in the prospective risk assessment of antibiotics. Abstract : In this study we propose a modelling approach to estimate antibiotic resistance development risks in environmental compartments and apply it to estimate risks in an intensive aquaculture pond scenario. Our study indicates that aquaculture pond sediments can be considered hot-spots for antibiotic resistance development and sets the ground for the inclusion of antibiotic resistance endpoints in the prospective risk assessment of antibiotics.