Control of chromosome interactions by condensin complexes. (June 2015)

• Record Type: Journal Article
• Authors: Frosi, Yuri; Haering, Christian H
• Is Part Of: Current opinion in cell biology. Volume 34(2015)
• Page Start: 94
• Page End: 100
• Publication Date: 2015-06
• Subjects: Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2015.05.008
• Languages: English
• ISSNs: 0955-0674

Abstract

Highlights: Condensin function: global regulators of genome topology? Condensin architecture: rods, rings, or both? Condensin mechanism: holding chromosomes together or driving them apart? Abstract : Although condensin protein complexes have long been known for their central role during the formation of mitotic chromosomes, new evidence suggests they also act as global regulators of genome topology during all phases of the cell cycle. By controlling intra-chromosomal and inter-chromosomal DNA interactions, condensins function in various contexts of chromosome biology, from the regulation of transcription to the unpairing of homologous chromosomes. This review highlights recent advances in understanding how these global functions might be intimately linked to the molecular architecture of condensins and their extraordinary mode of binding to DNA.