Inhibition of BMP9 Induced Bone Formation by Salicylic-acid Polymer Capping. (2019)

• Record Type: Journal Article
• Authors: Acri, Timothy M.; Laird, Noah Z.; Hong, Liu; Chakka, Jaidev L.; Shin, Kyungsup; Elangovan, Satheesh; Salem, Aliasger K.
• Is Part Of: MRS advances. Volume 4:Number 64(2019)
• Page Start: 3505
• Page End: 3512
• Publication Date: 2019
• Subjects: polymer, -- bone, -- biomaterial, -- biomedical; Electrical engineering -- Congresses; Physics -- Congresses; Materials -- Research -- Congresses; Materials science -- Congresses; 620.11
• DOI: 10.1557/adv.2020.61
• Languages: English
• ISSNs: 2059-8521

Abstract

Abstract: This work focuses on the development of a system to control the formation of bone to complement developments that have enabled potent regeneration of bony tissue. Scaffolds were fabricated with chemically modified RNA encoding for bone morphogenetic protein-9 (cmBMP9) and capped with salicylic acid (SA)-containing polymer (SAPAE). The goal was to determine if SAPAE could inhibit the formation of bone in a pilot animal study since cmBMP9 has been demonstrated to be highly effective in regenerating bone in a rat calvarial defect model. The results indicated that cmBMP9 increased bone formation (30% increase in area covered compared to control) and that SAPAE trended toward reducing the bone formation. These results suggest SAPAE could be useful as a chemical agent in reducing unwanted bone formation in implants loaded with cmBMP9.