Fungal keratitis: Pathogenesis, diagnosis and prevention. (January 2020)

• Record Type: Journal Article
• Authors: Niu, Lingzhi; Liu, Xin; Ma, Zhiming; Yin, Yuan; Sun, Lixia; Yang, Longfei; Zheng, Yajuan
• Is Part Of: Microbial pathogenesis. Volume 138(2020)
• Publication Date: 2020-01
• Subjects: Fungal keratitis -- Pathogenesis -- Diagnosis -- Prevention; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2019.103802
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: As a kind of serious, potentially sight-threatening corneal infections with poor prognosis, fungal keratitis can bring a heavy economic burden to patients and seriously affect the quality of life, especially those in developing countries where fungal keratitis is more prevalent. Typical clinical features include immune rings, satellite lesions, pseudopods, hypha moss, hypopyon and endothelial plaques. The ideal therapeutic effects could not be achieved by current treatments for many reasons. Therefore, under the current status, understanding the pathogenesis, early diagnosis and prevention strategies might be of great importance. Here, in this review, we discuss the recent progresses that may advance our understanding of pathogenesis, early diagnosis and prevention of fungal keratitis. Highlights: The pathogenesis of fungal keratitis (Aspergillus keratitis) was summarized. The diagnosis of fungal keratitis was compared. Recent advances in fungal keratitis prevention were reviewed.