Assessing the toxicity in vitro of degradation products from deoxynivalenol photocatalytic degradation by using upconversion nanoparticles@TiO2 composite. (January 2020)

• Record Type: Journal Article
• Authors: Zhou, You; Wu, Shijia; Wang, Fang; Li, Qian; He, Chuxian; Duan, Nuo; Wang, Zhouping
• Is Part Of: Chemosphere. Volume 238(2020)
• Publication Date: 2020-01
• Subjects: Deoxynivalenol -- Toxicity assessment -- In vitro -- Wastewater treatment -- Photocatalysis -- Upconversion nanoparticles@TiO2; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2019.124648
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Deoxynivalenol (DON) is one of the most globally prevalent mycotoxins mainly produced by Fusarium species. It can cause pollution to water environmental quality due to its water solubility. Therefore, it is necessary to develop a green and efficient detoxification technology for DON. More importantly, the toxicity of the degradation products should be assessed. Photocatalytic degradation technology has attracted increasing attention in the field of pollutants treatment, especially for wastewater treatment. Herein, the as-prepared NaYF4 :Yb, Tm@TiO2 composite (UCNP@TiO2 ) was employed as a novel photocatalyst for the NIR-enhanced photocatalytic degradation of DON. Three intermediate products were identified by using the ESI/MS analysis and secondary mass spectrogram, with the m/z values of 329.399, 311.243 and 280.913, respectively. Furthermore, the in vitro safety of the product mixtures with various degradation time (30 min, 60 min, 90 min and 120 min) were evaluated through the influences on cell viability, cell morphology, cell cycle, intracellular reactive oxygen species (ROS) level, cell apoptosis and antioxidant capacity of HepG2 cells. There were no significant differences in these investigated indicators between the control (free of DON) and 120 min products treatment. Overall, the results indicated that the toxicity of degradation products after 120 min irradiation was much lower and even nontoxic than that of DON. Graphical abstract: Image 1 Highlights: UCNP@TiO2 composite was employed as the photocatalyst for degradation of DON, 100% of DON was degraded after 120 min. Three intermediate products were identified, chemical structures were deduced, and their toxicity was conjectured. The toxicity in vitro of DON products were systematically researched by studying the influences on cell viability etc. The toxicity of degradation products after 120 min irradiation were much lower and even nontoxic than that of DON.