Microwave‐Assisted Multicomponent Reaction: A Green and Catalyst‐Free Method for the Synthesis of Poly‐Functionalized 1, 4‐Dihydropyridines. Issue 32 (27th August 2019)

• Record Type: Journal Article
• Authors: Maddila, Suresh; Nagaraju, Kerru; Chinnam, Sampath; Jonnalagadda, Sreekantha B
• Is Part Of: ChemistrySelect. Volume 4:Issue 32(2019)
• Page Start: 9451
• Page End: 9454
• Publication Date: 2019-08-27
• Subjects: Catalyst-free -- 1, 4-Dihydropyridine -- Four-component reactions -- Green synthesis -- Microwave irradiation -- One-pot reaction; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201902779
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A facile and an efficient procedure for the synthesis of poly‐substituted 1, 4‐dihydropyridine derivatives under catalyst‐free conditions has been established by a one‐pot multi‐component reaction in EtOH solvent under microwave irradiation (150 W). The remarkable benefits of this approach are: simple operation, non‐toxic, short reaction time (< 5 min), excellent yields (93‐98%), no column chromatography, clean reaction profile and environmentally friendly reaction. Abstract : A facile and an efficient procedure for the synthesis of poly‐substituted 1, 4‐dihydropyridine derivatives under catalyst‐free conditions has been established by a one‐pot multi‐component reaction in EtOH solvent under microwave irradiation at room temperature. The remarkable benefits of this approach are: simple operation, non‐toxic, short reaction time (< 5 min), excellent yields (93‐98%), no column chromatography, clean reaction profile and environmentally friendly reaction.