Correlating Anticancer Drug Delivery Efficiency with Vascular Permeability of Renal Clearable Versus Non‐renal Clearable Nanocarriers. (24th July 2019)

• Record Type: Journal Article
• Authors: Peng, Chuanqi; Yu, Mengxiao; Hsieh, Jer‐Tsong; Kapur, Payal; Zheng, Jie
• Is Part Of: Angewandte Chemie. Volume 131:Number 35(2019)
• Page Start: 12204
• Page End: 12208
• Publication Date: 2019-07-24
• Subjects: Gold-Nanopartikel -- Intratumoraler Transport -- Therapeutischer Index -- Vaskuläre Permeabilität -- Wirkstoff-Transport; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201905738
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Enhancing tumor targeting of nanocarriers has been a major strategy for advancing clinical translation of cancer nanomedicines. Herein, we report a head‐to‐head comparison between 5 nm renal clearable and 30 nm non‐renal clearable gold nanoparticle (AuNP)‐based drug delivery systems (DDSs) in the delivery of doxorubicin (DOX). While the two DDSs themselves had comparable tumor targeting, we found their different vascular permeability played an even more important role than blood retention in the delivery and intratumoral transport of DOX, of which tumor accumulation, efficacy, and therapeutic index were enhanced 2, 7, and 10‐fold, respectively, for the 5 nm DDS over 30 nm one. These findings indicate that ultrahigh vascular permeability of renal clearable nanocarriers can be utilized to further improve anticancer drug delivery without the need for prolonged blood retention. Abstract : Total durchlässig : Die ultrahohe vaskuläre Permeabilität von renal ausscheidbaren Gold‐Nanopartikeln kann genutzt werden, um Wirkstofftransport, intratumoralen Transport und therapeutische Wirksamkeit ohne die Notwendigkeit langer Blutretention zu verbessern.